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PacBio Literature

Application brief — Germline variant detection with the Onso system

Powered by sequencing by binding (SBB) chemistry, the PacBio short- read Onso platform delivers extraordinary base-calling accuracy (90% of bases at ≥Q40), setting a new standard in genetic research. This remarkable accuracy instills a new level of confidence in sequencing data and improves the ability to characterize challenging genetic variations through genome- wide and targeted approaches.

Application note — Comprehensive genotyping with the PureTarget repeat expansion panel and HiFi sequencing

Powered by the exceptional accuracy of HiFi sequencing and the Tandem Repeat Genotyping Tool (TRGT), the PacBio® PureTarget™ repeat expansion panel offers more comprehensive genotyping for 20 of the most important repeat expansions for human health. This application note demonstrates the performance of the PureTarget repeat expansion panel, and presents the PureTarget panel as a scalable, more comprehensive solution for profiling repeat expansions, compared to legacy genotyping and next-generation sequencing methods.
  |  2024

PureTarget brochure

PureTarget offers an easy and scalable workflow to capture repeat expansions and brings you from sample to answer in three days. Compatible with the RevioTM and Sequel® II systems, PureTarget libraries can be multiplexed with up to 48 samples, generating deep coverage across the 20-gene target panel.

Application-Brief — HiFi-Target-Enrichment-Best-Practices

With HiFi target enrichment you can easily and cost-effectively sequence just the genes you care about at scale. Design custom gene panels with our partners at Twist, sequence them with long and accurate HiFi reads, and get all the benefits you expect from HiFi reads: comprehensive detection of single nucleotide variants, structural variants, and indels. HiFi target enrichment is the only technology that can resolve complex gene families like HLA or Cytochrome P450 genes with haplotype resolution.​
  |  2024

Brochure — Nanobind PanDNA kit

The all-new PacBio® Nanobind® PanDNA kit consolidates the capabilities of our existing sample-specific offerings into a single solution for DNA extraction. This kit provides users with an all-in-one extraction experience that can be used with a wide range of sample types. The PanDNA kit supports high-quality extraction from cultured cells, bacteria, whole blood, tissue, plant nuclei, and insect samples.
  |  2024

Technical note — High throughput DNA shearing using Hamilton Microlab Prep

The whole genome sequencing (WGS) application requires an up-front mechanical DNA shearing step to transform genomic DNA into fragment sizes appropriate for HiFi sequencing. With the Hamilton Microlab Prep system, this step can be performed in as little as 22 minutes for 24 samples at the cost of a pipette tip per sample. Here we describe the required equipment and consumables, best practices, and procedure for shearing DNA on the Microlab Prep system.
  |  2024

Onso system brochure

Powered by the innovative sequencing by binding (SBB®) technology, the Onso system delivers unprecedented accuracy and sensitivity to advance your critical and groundbreaking research.
  |  2024

Brochure — Plant + animal applied markets

PacBio® provides cutting-edge sequencing that allows scientists to unlock the genetic diversity of all species on earth. These tools can fuel discoveries in agriculture, biodiversity, and environmental health, and build toward a sustainable future.
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