Using the PacBio IsoSeq method to search for novel colorectal cancer biomarkers

Author(s): Ashby, Meredith and Komor, Malgorzata A. and Hiemstra, Annemieke C. and Pham, Thang V. and Piersma, Sander R. and Sebra, Robert P. and Han, Bo W. and Carvalho, Beatriz and Meijer, Gerrit A. and Jimenez, Connie R. and Fijneman, Remond JA

Early detection of colorectal cancer (CRC) and its precursor lesions (adenomas) is crucial to reduce mortality rates. The fecal immunochemical test (FIT) is a non-invasive CRC screening test that detects the blood-derived protein hemoglobin. However, FIT sensitivity is suboptimal especially in detection of CRC precursor lesions. As adenoma-to-carcinoma progression is accompanied by alternative splicing, tumor-specific proteins derived from alternatively spliced RNA transcripts might serve as candidate biomarkers for CRC detection.

Organization: PacBio
Year: 2017

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