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2021年09月07日

Full-Length Sequencing of CYP2D6 Locus with HiFi Reads Increasing Genotypes Accuracy 

Author(s): Zhu, Lei

The highly polymorphic CYP2D6 gene impacts the metabolism of 25% of the mostly prescribed drugs. Thus, accurate identification of variant CYP2D6 alleles in individuals is necessary for personalized medicine. PacBio HiFi sequencing produces long and accurate reads to identify variant regions. Here, we describe an end-to-end workflow for the characterization of full-length CYP2D6 by HiFi sequencing. 

Organization: PacBio
Year: 2021

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