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2021年06月01日

Analysis of 37,000 Caucasian samples reveals tight linkage between SNP RS9277534 and high resolution typing of HLA-DPB1

Author(s): Schöne, B. and Bergmann, S. and Lang, K and Hedrich, L and Andreas, J. M. and Schmidt, A. H. Lange, V and Petersdorf, E. W.

HLA-DPB1 mismatching between patients and unrelated donors is known to increase the risk of acute graft-versus-host-disease (GvHD) after hematopoietic stem cell transplantation. If only HLA-DPB1 mismatched donors are available, the genotype defined by the Single Nucleotide Polymorphism (SNP) rs9277534 can be used to select mismatched donors that are well-tolerated. However, since rs9277534 resides within the 3’ untranslated region (UTR), it usually is not analyzed during DPB1 routine typing.

Organization: DKMS Life Science Lab
Year: 2016

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